Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Aging
Identifieur interne : 001416 ( Main/Exploration ); précédent : 001415; suivant : 001417Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Aging
Auteurs : M S Gomes [Brésil] ; F N Hugo [Brésil] ; J B Hilgert [Brésil] ; M. Sant'Ana Filho [Brésil] ; D M P. Padilha [Brésil] ; E M Simonsick [États-Unis] ; L. Ferrucci [États-Unis] ; M A Reynolds [États-Unis]Source :
- International endodontic journal [ 0143-2885 ] ; 2015.
Abstract
To evaluate whether the presence of apical periodontitis (AP), root canal treatment (RCT) and endodontic burden (EB) – as the sum of AP and RCT sites – were associated with long-term risk of incident cardiovascular events (CVE), including cardiovascular-related mortality, using data on participants in the Baltimore Longitudinal Study of Aging (BLSA).
This retrospective cohort included 278 dentate participants in the BLSA with complete medical and dental examinations. Periodontal disease (PD) and missing teeth were recorded. Total number of AP and RCT sites was determined from panoramic radiographs. EB was calculated as the sum of AP and RCT sites. Oral inflammatory burden (OIB) was calculated combining PD and EB. The main outcome was, incident CVE including angina, myocardial infarction and cardiovascular-related death. Participants were monitored for up to 44 years (mean=17.4±11.1 years) following dental examination. Relative Risks (RR) were calculated through Poisson regression models, estimating the relationship between AP, RCT, EB, PD, OIB and incident CVE.
Mean age at baseline was 55.0±16.8 years and 51.4% were men. Sixty two participants (22.3%) developed CVE. Bivariate analysis showed that PD, EB, number of teeth and OIB were associated with incident CVE. Multivariate models, adjusted for socio-demographic and medical variables, showed that age≥60 years (RR=3.07, 95%CI=1.68-5.62), hypertension (RR=2.0, 95%CI=1.16-3.46) and EB≥3 (RR=1.77, 95%CI=1.04-3.02) were independently associated with incident CVE. The association between OIB and incident CVE was reduced to non-significance after adjustments (RR=1.97, 95%CI=0.83-4.70).
EB in mid-life was an independent predictor of CVE among community-dwelling participants in the BLSA. Prospective studies are required to evaluate cardiovascular risk reduction with the treatment of AP.
Url:
DOI: 10.1111/iej.12468
PubMed: 26011008
PubMed Central: 5134837
Affiliations:
- Brésil, États-Unis
- Maryland, Rio Grande do Sul
- College Park (Maryland), Porto Alegre
- Université du Maryland, Université fédérale du Rio Grande do Sul
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Aim</title>
<p id="P1">To evaluate whether the presence of apical periodontitis (AP), root canal treatment (RCT) and endodontic burden (EB) – as the sum of AP and RCT sites – were associated with long-term risk of incident cardiovascular events (CVE), including cardiovascular-related mortality, using data on participants in the Baltimore Longitudinal Study of Aging (BLSA).</p>
</sec>
<sec id="S2"><title>Methodology</title>
<p id="P2">This retrospective cohort included 278 dentate participants in the BLSA with complete medical and dental examinations. Periodontal disease (PD) and missing teeth were recorded. Total number of AP and RCT sites was determined from panoramic radiographs. EB was calculated as the sum of AP and RCT sites. Oral inflammatory burden (OIB) was calculated combining PD and EB. The main outcome was, incident CVE including angina, myocardial infarction and cardiovascular-related death. Participants were monitored for up to 44 years (mean=17.4±11.1 years) following dental examination. Relative Risks (RR) were calculated through Poisson regression models, estimating the relationship between AP, RCT, EB, PD, OIB and incident CVE.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Mean age at baseline was 55.0±16.8 years and 51.4% were men. Sixty two participants (22.3%) developed CVE. Bivariate analysis showed that PD, EB, number of teeth and OIB were associated with incident CVE. Multivariate models, adjusted for socio-demographic and medical variables, showed that age≥60 years (RR=3.07, 95%CI=1.68-5.62), hypertension (RR=2.0, 95%CI=1.16-3.46) and EB≥3 (RR=1.77, 95%CI=1.04-3.02) were independently associated with incident CVE. The association between OIB and incident CVE was reduced to non-significance after adjustments (RR=1.97, 95%CI=0.83-4.70).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">EB in mid-life was an independent predictor of CVE among community-dwelling participants in the BLSA. Prospective studies are required to evaluate cardiovascular risk reduction with the treatment of AP.</p>
</sec>
</div>
</front>
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<name sortKey="Hilgert, J B" sort="Hilgert, J B" uniqKey="Hilgert J" first="J B" last="Hilgert">J B Hilgert</name>
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<country name="États-Unis"><region name="Maryland"><name sortKey="Simonsick, E M" sort="Simonsick, E M" uniqKey="Simonsick E" first="E M" last="Simonsick">E M Simonsick</name>
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